Myelodysplastic Syndrome

Staging/Prognosis


IPSS Calculaor (qxMD)


Treatment




Links


Questions:

MDS with thrombocytosis but not 5q-.

RARS-T syndrome (easily confused with pre-fibrotic myelofibrosis). Should prompt chromosome analysis (looking for 7- og tri(8), for example) and MPL/JAK-2 analysis.

MDS with Auer Rods: MDS or AML?

If less than 10% blasts in BM and less than 5% in blood, this is RAEB-2.

Oral Demethylating agent?

Sapacitabine, which is given orally 3 or 7 days. A phase 2 study presented at ASH 2010 showed that 29-30% of patients, who had failed azacytidine or decitabine, responded. This may be big.

Links:

How I treat (Blood).