Aplastic anemia

Study comparing CSA to CSA + ATG from 1999 It showed that the combination of Anti-thymocyte globulin and cyclosporine was superior in terms of response rates. There was no difference in survival at 6 months (93% and 91%, so both groups did very well).

Large EMBT Study showing the outcome in three age groups after treatment with CSA or ATG. Age groups were under 50, 50-60 and 60+. 5-year Survival was 67%, 57% and 50%, respectively. Survival was also influenced by neutrophil count at diagnosis (<200,>500).

Interesting study showing that HD cyclophosphamide (200mg/kg giver IV over 4 days) induce good, durable responses. Age group was 40 to 70. The patients were previously untreated.